Tributyrin
A source of butyrate
In plain language
Three butyrate units linked to one glycerol backbone. A fat that releases butyrate as it is digested.
CoreBiome® is the branded tributyrin selected for development.
Tributyrin, explainedFormula 01
Two actives.
Every amount printed.
CoreBiome® + PepZinGI®
Formula 01 is a two-ingredient capsule in development for the digestive system: tributyrin, a source of butyrate, and zinc L-carnosine.
In development · targeting late 2026Why these two
The two actives
Behind the names.
The ingredient form is part of its identity. Here is what each one is, and where to read what the research did and did not measure.
Zinc L-carnosine
The mucosal complement
In plain language
Zinc bound to L-carnosine, a dipeptide made from beta-alanine and L-histidine, in one ingredient complex.
PepZinGI® is the branded zinc L-carnosine selected for development.
Zinc L-carnosine, explainedSimplified ingredient diagrams. Illustrations are not molecular models.
Why these two
Fuel for the lining,
and the lining itself.
The cells lining the colon run on butyrate. Zinc L-carnosine has been studied for how that lining holds up under stress. One ingredient for each, and nothing that dilutes either.
Butyrate is made in the colon when bacteria ferment fiber, and it is the main energy source for the cells that line it. Most people eat less fiber than recommended, which is why a direct source is interesting. We chose tributyrin, a fat that carries three butyrate units, over the salts, because it releases butyrate as it is digested rather than all at once in the stomach, adds no sodium or calcium, and is easier to live with.
Zinc L-carnosine complements that from a different angle. Two small human crossover trials measured intestinal permeability in healthy volunteers under challenge, and reported that the rise was blunted with zinc L-carnosine. Those are small studies with a physiological endpoint, not a promise about how anyone will feel, and we describe them that way.
Two actives means two things we can assay, print, and stand behind. Everything below was considered and set aside for a reason we are willing to publish.
Read the science with its limitsWhat we set aside
Considered, and left out.
A short formula is a set of decisions. These are the ones we made against common additions, and why.
Butyrate salts
Sodium and calcium butyrate deliver butyrate directly and have the longer research history. They also add sodium or calcium with every dose, and their odor is difficult to contain. Tributyrin carries the butyrate inside a fat molecule, which is why we chose it, and why odor is a specification we test rather than a hope.
Fiber in a capsule
Fermentable fiber is the most reliable way to raise butyrate, but useful amounts are measured in grams. A capsule holds a fraction of one. Fiber at capsule scale is a label decoration. If we offer fiber, it will be a powder and its own product.
Glutamine
Widely paired with gut-lining ingredients, and studied at five to fifteen grams a day. That is a scoop, not a capsule. Putting a few hundred milligrams in Formula 01 would let us print the name without delivering the amount the research used.
Probiotics
Live organisms have their own storage, viability, and strain-specific evidence questions, and would make the formula harder to test and to explain. Formula 01 stays with two well-defined molecules whose amounts can be verified by assay.
Herbal extracts, collagen, and blends
Each would add a line to the label and a story to the listing without adding evidence we could stand behind at the amount a capsule allows. Every active in Formula 01 is there because we can name its amount, its source, and the study behind it.
From ingredient to capsule
A liquid and a powder,
in one capsule.
Tributyrin is a liquid fat. Zinc L-carnosine is a powder. Getting both into a single capsule that stays stable, keeps its odor inside, and delivers the printed amount is the central formulation problem of Formula 01, and there is more than one way to solve it.
Bench prototypes on production-grade material decide the format: fill weight, capsule size, seal, and how the finished capsule holds up in real-time and accelerated stability testing. We publish the result, not the guess.
Where development stands
The path
to the first lot.
Five stages, in order. Each one has a written gate, and nothing ships until the last one clears. This section is updated as gates clear.
Done
Ingredients selected
Tributyrin and zinc L-carnosine chosen as the two actives. Everything else set aside.
Now
Manufacturer qualification and prototypes
Supplier documentation collected. Bench prototypes made on production-grade material to confirm fill, capsule compatibility, and odor.
Next
Specification and stability
Final amounts, capsule format, packaging, and the finished-product test plan written down and signed off. Real-time and accelerated stability begins.
Later
Production and release testing
First run manufactured. Every lot tested for identity, amount, contaminants, and odor before release. Results published by lot.
Later
Available on Amazon US
Targeting late 2026. People on the launch list hear first.
What comes with the jar
Three things that don’t change.
Whatever the final amounts and format turn out to be, these hold.
- 01
Every active printed by amount
No proprietary blends. The label states the amount of each active, and for tributyrin that means the net active amount, not the weight of the carrier it arrives in.
- 02
Every lot tested, results public
Each released lot gets finished-product testing for identity, amount, contaminants, and odor, and the certificate is published on this site under the lot number printed on the jar.
- 03
Evidence kept in context
Research on an ingredient is not research on this formula. We label which is which, cite the study, and say what it did not measure.
Useful answers
About Formula 01.
What we can say now, and what has to wait for the specification.
When will it be available?
We are targeting late 2026, on Amazon US first. The date depends on bench work, stability testing, and a first production run, in that order. The launch list hears first, and we will say so here the moment the date is fixed.
What exactly is in it?
Two actives: tributyrin (CoreBiome®) and zinc L-carnosine (PepZinGI®). No proprietary blend, no fillers presented as actives. The final amounts, the capsule shell, and any excipients needed to make a stable capsule will be printed on the label and published here first.
What are the amounts?
The tributyrin amount is being finalized between bench prototypes and stability results, and it will be stated as net active tributyrin, not the weight of a carrier. The zinc L-carnosine working amount is 75 mg, the level used in the published human research, which provides about 17 mg of zinc. Both numbers become final when the specification is signed.
Does it contain a lot of zinc?
Yes, and we will say so on the label. 75 mg of zinc L-carnosine provides about 17 mg of elemental zinc, more than the daily value. If you already take a multivitamin or a separate zinc supplement, add it up, and ask a clinician or pharmacist if you are unsure.
Will it smell?
Butyrate products are known for it. Tributyrin is far milder than the salts but not odorless, so the finished capsule carries a measurable odor specification, and every lot is tested against it in the packaging it ships in. If a lot fails, it does not ship.
Is the research on Formula 01 itself?
No. Every study we cite is on an ingredient, and we say so each time. There is no finished-product trial of Formula 01, and nothing on this site should be read as if there were. The Learn pages explain what each study measured and what it did not.
What is a capsule format decision?
Tributyrin is a liquid fat and zinc L-carnosine is a powder. Getting both into one capsule that stays stable is a real formulation problem, and there is more than one way to solve it. Bench prototypes on production-grade material decide the format. It gets published with the label.
Are the images of a finished product?
No. The jar and capsule images are concept visuals, and the colored-pencil diagrams simplify composition. They show relationships between the parts, not molecular geometry. Formula 01 is a working name until the final name clears review.
The launch list
Hear about it when it’s real.
Formula 01 is targeting late 2026. Leave your email and you’ll get three messages: the final label, the first lot’s test results, and the launch date.
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